Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion

Abstract Patients with tuberculous pleural effusion (TPE) or malignant effusions (MPE) frequently have similar fluid profiles. New biomarkers for the differential diagnosis of TPE are required. We determined whether cytokine profiles in PE patients could aid TPE. 30 TPE, MPE, 14 empyema (EMP) and parapneumonic (PPE) were enrolled between Dec 2018 2019. The levels interleukin (IL)-6, IL-18, IL-27, CXCL8, CCL-1 IP-10 by ELISA along measurements adenosine deaminase (ADA). best predictors combined ADA.IL-27 [optimal cut-off value = 42.68 (10 3 U ng/l 2 ), sensitivity 100%, specificity 98.28%], ADA [cut off 27.5 (IU/l), 90%, 96.5%] IL-27 [cut-off 2363 (pg/ml), 96.7%, 98.3%, p ? 0.0001]. A high level IL-6 3260 67.2%], CXCL8 144.5 93.3%, 58.6%], CCL1 54 70.7%] 891.9 83.3%, 48.3%] also predictive High ADA.IL-27, differentiate non-TPE improved diagnostic accuracy may be useful clinically.